Mandible & maxilla
Odontogenic carcinoma
Sclerosing odontogenic carcinoma

Topic Completed: 13 April 2020

Minor changes: 3 December 2020

Copyright: 2020,, Inc.

PubMed search: sclerosing odontogenic carcinoma

Nathan Lee, D.M.D.
Tony Ng, M.D., Ph.D.
Page views in 2020: 516
Page views in 2021 to date: 50
Cite this page: Lee N, Ng T. Sclerosing odontogenic carcinoma. website. Accessed January 24th, 2021.
Definition / general
Essential features
  • Rare, newly defined odontogenic malignancy that is a diagnosis of exclusion
  • Variable radiographic appearance but has the invasive and destructive features of a malignancy
  • Markedly sclerotic stroma containing bland epithelial cords to nests but with infiltrative margins
ICD coding
  • ICD-O: 9270/3 - Odontogenic tumor, malignant
  • ICD-9
    • 170.0 - Malignant neoplasm of bones of skull and face, except mandible
    • 170.1 - Malignant neoplasm of mandible
  • ICD-10
    • C41.0 - Malignant neoplasm of bones of skull and face
    • C41.1 - Malignant neoplasm of mandible
  • Neoplastic but exact pathophysiology is not known at this time
Clinical features
  • Based on a combination of clinical examination and definitive diagnosis requires correlation between both radiographic and histologic findings
Radiology description
Radiology images

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Infiltrative ground glass radiolucency

Prognostic factors
Case reports
Clinical images

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Anterior mandible exophytic mass

Gross description
Gross images

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Mandible tumor involving skin

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Nathan Lee, D.M.D.

Architectural invasion

Bland cytology

Hypercellular tumor

Invasive clear cells

Hypercellular clear cell variant

Bland clear cells





Sample pathology report
  • Left maxilla, resection:
    • Sclerosing odontogenic carcinoma (see synoptic report)
Differential diagnosis
Board review style question #1
A 62 year old male presented with a destructive and invasive odontogenic lesion involving the left maxilla and sinus. Which of the following immunohistochemical stain results would you expect from this sclerosing odontogenic carcinoma?

  1. CD117 positive
  2. CK20 positive
  3. Desmin positive
  4. p63 positive
  5. S100 positive
Board review style answer #1
Board review style question #2
A 62 year old male presented with a destructive and invasive lesion involving the midline maxilla and left sinus. Which of the following entities would not be on the differential diagnosis?

  1. Metastatic squamous cell carcinoma
  2. Olfactory neuroblastoma
  3. Primary intraosseous odontogenic carcinoma
  4. Sclerosing odontogenic carcinoma
  5. Squamous odontogenic carcinoma
Board review style answer #2
B. Olfactory neuroblastoma

Reference: Sclerosing odontogenic carcinoma

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