Thymic carcinoma


Topic Completed: 1 December 2012

Minor changes: 10 June 2020

Copyright: 2003-2021,, Inc.

PubMed Search: NUT midline carcinoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2020: 1,695
Page views in 2021 to date: 1,465
Cite this page: Gulwani H. NUT. website. Accessed December 8th, 2021.
Definition / general
  • Aggressive subset of squamous cell carcinoma defined by rearrangement of NUT (NUclear protein in Testis) gene on #15 to other genes, usually BRD4 on #19 (Head Neck Pathol 2011;5:31)
  • First described in 1991 (Cancer Res 1991;51:3327)
  • Originally thought to be limited to mediastinum but 35% occur in head and neck
  • Highly aggressive, with median survival of 7 months due to ineffective chemotherapy
  • Must rule out for any poorly differentiated epithelioid mediastinal tumor, regardless of age
  • Head, neck and mediastinum of younger individuals
Microscopic (histologic) description
  • Undifferentiated epithelioid or round cell malignant cells, variable focal squamous differentiation
Microscopic (histologic) images

Images hosted on other servers:

Head and neck

Various images

Cytology images

Images hosted on other servers:

Head and neck

Back to top
Image 01 Image 02