Mediastinum
Thymic carcinoma
NUT
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 December 2012
Last staff update: 10 June 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: NUT midline carcinoma mediastinum
Table of Contents
Definition / general | Sites | Microscopic (histologic) description | Microscopic (histologic) images | Cytology imagesCite this page: Gulwani H. NUT. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mediastinumNMC.html. Accessed June 8th, 2023.
Definition / general
- Aggressive subset of squamous cell carcinoma defined by rearrangement of NUT (NUclear protein in Testis) gene on #15 to other genes, usually BRD4 on #19 (Head Neck Pathol 2011;5:31)
- First described in 1991 (Cancer Res 1991;51:3327)
- Originally thought to be limited to mediastinum but 35% occur in head and neck
- Highly aggressive, with median survival of 7 months due to ineffective chemotherapy
- Must rule out for any poorly differentiated epithelioid mediastinal tumor, regardless of age
Sites
- Head, neck and mediastinum of younger individuals
Microscopic (histologic) description
- Undifferentiated epithelioid or round cell malignant cells, variable focal squamous differentiation
Microscopic (histologic) images
Images hosted on other servers:
Head and neck
Various images
Cytology images
Images hosted on other servers:
Head and neck
