Mediastinum
Thymic carcinoma
Basaloid
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 December 2012
Last staff update: 10 June 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Basaloid squamous cell carcinoma[TI]
Table of Contents
Definition / general | Clinical features | Prognostic factors | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy descriptionCite this page: Gulwani H. Basaloid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mediastinumbasaloidscc.html. Accessed June 9th, 2023.
Definition / general
- Primary thymic tumor or metastatic tumor to mediastinum from oropharynx, hypopharynx, larynx, esophagus, lung, anorectum
Clinical features
- Present with intrathoracic mass
- Primary tumors are associated with multilocular thymic cysts
- Capable of aggressive behavior and significant mortality (Am J Surg Pathol 2009;33:1113)
Prognostic factors
- Good prognosis with few fatalities if well differentiated
Microscopic (histologic) description
- Nests, cords and sheets of small polygonal cells with minimal cytoplasm, hyperchromatic round nuclei, abundant mitotic figures
- No nuclear molding
- Separated by myxoid or eosinophilic stroma
- May have peripheral pallisading of nuclei
- May have areas of squamous differentiation with keratin pearls or stromal mucin containing gland-like profiles
- May have cystic structures
Microscopic (histologic) images
Images hosted on other servers:
Prominent peripheral palisading
Negative stains
- Neuroendocrine markers
Electron microscopy description
- Poorly differentiated squamous proliferation with limited cytoplasmic tonofilaments, well formed desmosomes, redundant basal lamina
- No neurosecretory granules
