Thymic carcinoma


Last author update: 1 December 2012
Last staff update: 10 June 2020

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PubMed Search: Basaloid squamous cell carcinoma[TI]

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Basaloid. website. Accessed June 9th, 2023.
Definition / general
  • Primary thymic tumor or metastatic tumor to mediastinum from oropharynx, hypopharynx, larynx, esophagus, lung, anorectum
Clinical features
  • Present with intrathoracic mass
  • Primary tumors are associated with multilocular thymic cysts
  • Capable of aggressive behavior and significant mortality (Am J Surg Pathol 2009;33:1113)
Prognostic factors
  • Good prognosis with few fatalities if well differentiated
Microscopic (histologic) description
  • Nests, cords and sheets of small polygonal cells with minimal cytoplasm, hyperchromatic round nuclei, abundant mitotic figures
  • No nuclear molding
  • Separated by myxoid or eosinophilic stroma
  • May have peripheral pallisading of nuclei
  • May have areas of squamous differentiation with keratin pearls or stromal mucin containing gland-like profiles
  • May have cystic structures
Microscopic (histologic) images

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Prominent peripheral palisading

Positive stains
Negative stains
  • Neuroendocrine markers
Electron microscopy description
  • Poorly differentiated squamous proliferation with limited cytoplasmic tonofilaments, well formed desmosomes, redundant basal lamina
  • No neurosecretory granules
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