Mediastinum
Cystic lesions
Seminoma-cystic
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 December 2012
Last staff update: 16 August 2022
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Seminoma cystic
Table of Contents
Definition / general | Clinical features | Case reports | Gross description | Microscopic (histologic) description | Positive stainsCite this page: Gulwani H. Seminoma-cystic. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mediastinumcysticseminoma.html. Accessed June 1st, 2023.
Definition / general
- Cysts are due to degenerative changes, may be prominent (Am J Surg Pathol 1995;19:1047)
- Usually in anterosuperior mediastinum
Clinical features
- Associated with Klinefelter syndrome (XXY), hematologic abnormalities
Case reports
- Prominent cystic change and high CA19-9 level of cystic fluid (Ann Thorac Surg 2009;88:1693)
Gross description
- Variable cystic contents, unilocular or multilocular
Microscopic (histologic) description
- Seminoma cells present in cyst wall but may not be numerous
- Have glycogen rich cytoplasm with marked retraction, coarse chromatin with prominent nucleoli, variable mitotic figures
- Subdivided by fine fibrous trabeculae
- Associated with germinal centers, giant cells
- No cholesterol granulomas (may have other granulomas), no cartilage, no smooth muscle
