Mediastinum
Soft tissue lesions
Ganglioneuroma


Topic Completed: 1 December 2012

Minor changes: 4 February 2020

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Ganglioneuroma[TI] mediastinum

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Ganglioneuroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mediastinumganglioneuroma.html. Accessed May 27th, 2020.
Definition / general
  • Benign neural tumor; more common than neuroblastoma or ganglioneuroblastoma
Epidemiology
  • Usually children; also age 20 - 39 years
Clinical features
  • No symptoms in most cases
  • Rarely watery diarrhea from vasoactive intestinal peptide (VIP) synthesis or symptoms of spinal nerve root compression
  • Clinical diagnosis is aided by integrating age, clinical findings, location, imaging (AJR Am J Roentgenol 2011;197:W643)
Case reports
Treatment
  • Excision is curative
Gross description
  • Encapsulated, glistening tumor
  • May have intradural growth and dumbbell shape
  • Soft, yellow-gray cut surface, may have cystic and fatty areas, usually no necrosis
Gross images

Images hosted on other servers:

21 cm ganglioneuroma

Well circumscribed
tumor with whorled
appearance

Microscopic (histologic) description
  • Spindle cell (Schwannian) proliferation similar to neurofibroma but with well formed ganglion cells, often in clusters and multinucleated
  • Focal lymphocytes present
Microscopic (histologic) images

Images hosted on other servers:

Spindled Schwann cells and scattered ganglion cells

Positive stains
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