Mediastinum
Nonneoplastic
Thymic follicular hyperplasia


Topic Completed: 1 December 2012

Minor changes: 20 February 2020

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Thymic follicular hyperplasia

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Thymic follicular hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mediastinumthymicfollicularhyper.html. Accessed August 8th, 2020.
Definition / general
  • Defined as substantial numbers of lymphoid follicles in thymus of adults
  • Thymus usually has normal size / weight
Clinical features
  • Present in 65% with myasthenia gravis
  • Also associated with hyperthyroidism, Addison disease, SLE, early HIV, multilocular cysts, other immune related diseases
  • Often different clinical history than true thymic hyperplasia (Pathologica 2009;101:175)
Microscopic (histologic) description
  • Follicles with germinal centers, medullary epithelial cells may be disordered or hypertrophied
Differential diagnosis
  • Normal lymphoid follicles of infants / children (few present)
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