Microbiology, parasitology & COVID-19
Viruses
Dengue fever
Author: Dragos C. Luca, M.D.
Last author update: 1 March 2014
Last staff update: 21 March 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Dengue fever
Table of Contents
Definition / general | Clinical presentation and diagnosis | Case reports | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Electron microscopy images | Additional referencesCite this page: Luca DC. Dengue fever. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/microbiologydenguefever.html. Accessed September 27th, 2023.
Definition / general
- Transmitted by Stegomyia aegypti (formerly Aedes aegypti) mosquito (Wikipedia: Aedes aegypti Biting Human [Image])
- Causes bone marrow suppression, DIC and thrombopathy (Baillieres Best Pract Res Clin Haematol 2000;13:261)
- Also known as "breakbone" fever
Clinical presentation and diagnosis
- Characteristic skin rash similar to measles
- Fever, headache, muscle and joint pain
- Rarely presents with life threatening hemorrhagic fever
- Leukopenia, lymphocytosis with atypical lymphocytes in peripheral blood
- Confirmation by serology or PCR
Case reports
- Patient with hemoglobin H disease and acute myeloid leukemia precipitated by dengue virus infection (Haematologica 2001;86:E17)
Treatment
- Usually supportive (oral rehydration, intravenous fluids, etc.)
Clinical images
Images hosted on other servers:
Typical rash of dengue fever
Aedes aegypti
Microscopic (histologic) description
- Bone marrow hypoplasia or hyperplasia
- Megakaryocytic hypoplasia with thrombocytopenia as the most common hematologic manifestation
- Occasional extreme plasmacytosis (Arch Pathol Lab Med 2003;127:1026)
- Hemophagocytosis and dysplastic changes (Kaohsiung J Med Sci 2005;21:34)
Microscopic (histologic) images
Images hosted on other servers:
Hemophagocytosis
Stars indicate erythrocytes phagocytized by a macrophage
Electron microscopy images
Images hosted on other servers:
Dengue virus virions
![Wikipedia: Aedes aegypti Biting Human [Image]](http://en.wikipedia.org/wiki/File:Aedes_aegypti_biting_human.jpg){kind=link}