Bone marrow neoplastic

Bone marrow - neoplastic myeloid

Myeloid / lymphoid neoplasms with eosinophilia and gene rearrangement

PDGFRB rearrangement

Topic Completed: 1 August 2011

Minor changes: 4 January 2022

Copyright: 2002-2022,, Inc.

PubMed Search: Myeloid neoplasm "PDGFRB rearrangement"

Nikhil Sangle, M.D.
Page views in 2021: 163
Page views in 2022 to date: 5
Cite this page: Sangle N. PDGFRB rearrangement. website. Accessed January 19th, 2022.
Definition / general
  • Very rare
  • Also called chronic myelomonocytic leukemia with eosinophilia associated with t(5;12)
  • PDGFRB is at 5q31-33
  • Bone marrow examination with tryptase stain, T cell clonal studies
  • Use of immunostains, cytogenetics and molecular studies to detect PDFGRB rearrangement and absence of BCR-ABL
  • Leukocytosis and eosinophilia
  • Variable monocytosis and neutrophilia
  • Anemia and thrombocytopenia
Molecular / cytogenetics description
  • t(5;12)(q31-q33;p12) or a variant translocation or ETV6-PDGFRB fusion gene
  • ETV6, previously known as TEL (Acta Haematol 2002;107:113)
Molecular / cytogenetics description

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FISH assays indicate rearrangement of PDGFRB

Differential diagnosis
Additional references
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