Nasal cavity, paranasal sinuses, nasopharynx

Other malignant tumors

Sinonasal glomangiopericytoma



Topic Completed: 1 November 2004

Minor changes: 21 September 2021

Copyright: 2004-2021, PathologyOutlines.com, Inc.

PubMed Search: Glomangiopericytoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Sinonasal glomangiopericytoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/nasalHPC.html. Accessed December 3rd, 2021.
Definition / general
  • Uncommon tumor of pericytic myoid differentiation (unlike soft tissue hemangiopericytoma)
  • WHO calls it glomangiopericytoma; also called myopericytoma, hemangiopericytoma - sinonasal type (J Laryngol Otol 2007;121:786)
  • Mean age 63 years, usually ages 40+ but range of 5 - 86 years; slight female predominance
  • Usually presents with airway obstruction or epistaxis in nasal cavity or paranasal sinus
  • Recurs locally (18%), no metastases; death due to disease is rare
Case reports
Treatment
  • Excision plus followup
Gross description
  • Resembles allergic polyp
  • Unilateral, unencapsulated, mean 3 cm, red to gray-pink, soft, edematous, fleshy to friable, often hemorrhagic
Microscopic (histologic) description
  • Diffuse growth with fascicular, solid or focally whorled pattern of spindled or round / oval tumor cells that arrange themselves around prominent, small, thin walled submucosal blood vessels
  • Cells have variable cytoplasm and nuclei, indistinct cell borders, occasionally are multinucleated
  • Minimal atypia, no necrosis, no / rare mitotic activity
  • Vessels are prominent with staghorn appearance and perivascular hyalinization
  • Often mast cells and eosinophils
  • Surface epithelium is intact and usually respiratory
Microscopic (histologic) images

Case #84

Bland spindled and round / oval cells with prominent blood vessels

CD34 highlights vessels but tumor cells are negative

Smooth muscle actin is diffusely positive

Positive stains
Negative stains
Electron microscopy description
  • Basal lamina surrounds individual cells, tapered cytoplasmic extensions, orderly bundles of filaments
Differential diagnosis
  • Glomus tumor:
    • Also a pericytic tumor with similar staining but extremely rare in sinonasal region
    • Composed of compact epithelioid cells
  • Lobular capillary hemangioma:
    • Lobular pattern at low power
    • Has spindled fibroblasts and prominent vessels but overall granulation tissue-like appearance with only small capillaries
  • Solitary fibrous tumor:
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