Nasal cavity, paranasal sinuses, nasopharynx

Benign tumors

Psammomatoid ossifying fibroma

Topic Completed: 1 November 2004

Minor changes: 28 December 2020

Copyright: 2004-2021,, Inc.

PubMed Search: Psammomatoid ossifying fibroma nasal

Nat Pernick, M.D.
Page views in 2020: 1,223
Page views in 2021 to date: 1,328
Cite this page: Pernick N. Psammomatoid ossifying fibroma. website. Accessed November 29th, 2021.
Definition / general
  • Distinctive solitary fibro-osseous lesion of young persons that affects orbit and paranasal sinuses
  • Affects extragnathic craniofacial bones (periorbital, frontal and ethmoid)
  • Slowly progressive, may invade and destroy surrounding tissue and cause bony erosion
  • Tends to recur after excision
Radiology description
  • Xray: expansile well circumscribed, partially radiolucent lesion surrounded by a thick bony wall
Case reports
  • Complete surgical excision
Microscopic (histologic) description
  • Numerous small, round ossicles (psammomatoid bodies) embedded in cellular fibrous stroma and within bony trabeculae
  • Stroma may be loose and fibroblastic or intensely cellular without collagen
  • Contains variably shaped cells with indistinct cytoplasmic borders and basophilic nuclei
  • Variable giant cells, stroma with cystic degeneration
  • Rare mitotic figures
  • No anaplasia, no necrosis
Differential diagnosis
  • Central cementifying fibroma: benign odontogenic jaw lesion, usually ages 20 - 39 years, female, has cementicles (related to dental cementum), not ossicles
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