Nasal cavity, paranasal sinuses, nasopharynx
Other nonneoplastic lesions
Respiratory epithelial adenomatoid hamartoma
Author: Nat Pernick, M.D.
Topic Completed: 1 November 2004
Minor changes: 8 October 2020
Copyright: 2004-2021, PathologyOutlines.com, Inc.
PubMed Search: Respiratory epithelial adenomatoid hamartoma nasal
Table of Contents
Definition / general | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Pernick N. Respiratory epithelial adenomatoid hamartoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/nasalrespepithadenohamart.html. Accessed September 16th, 2021.
Definition / general
- First described in 1995
- Usually posterior nasal septum of men
- Median age 58 years (range 27 - 82 years)
- Associated with chronic rhinosinusitis
Treatment
- Complete excision
- Usually doesn't recur
Gross description
- Polypoid or exophytic, rubbery, tan-brown, up to 4.9 cm but without destructive growth
Microscopic (histologic) description
- Proliferation of glandular spaces lined by ciliated epithelium or goblet cells
- Glands have thick, eosinophilic basement membranes
- Background resembles inflammatory polyp due to vascularization, edema and chronic inflammatory cells
Microscopic (histologic) images
Contributed by Semir Vranic, M.D., Ph.D.
5x
10x
CK7
Images hosted on other servers:
Numerous glands
lined by ciliated
respiratory epithelium
Each gland is
surrounded by an
eosinophilic, thick
basement membrane
Differential diagnosis
- Adenocarcinoma: back to back glands, occasional nuclear pleomorphism, prominent mitotic activity, perineural invasion, desmoplastic stroma
- Inflammatory polyp: has fewer glands
- Inverted papilloma: usually on lateral nasal wall not nasal septum, usually hyperplastic squamous epithelium with only few goblet cells, thin basement membrane, no / rare mucoserous glands
