Nasal cavity, paranasal sinuses, nasopharynx
Other nonneoplastic lesions
Respiratory epithelial adenomatoid hamartoma
Author: Nat Pernick, M.D.
Topic Completed: 1 November 2004
Minor changes: 3 March 2020
Copyright: 2004-2020, PathologyOutlines.com, Inc.
PubMed Search: Respiratory epithelial adenomatoid hamartoma nasal
Table of Contents
Definition / general | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Pernick N. Respiratory epithelial adenomatoid hamartoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/nasalrespepithadenohamart.html. Accessed September 18th, 2020.
Definition / general
- First described in 1995
- Usually posterior nasal septum of men
- Median age 58 years (range 27 - 82 years)
- Associated with chronic rhinosinusitis
Treatment
- Complete excision
- Usually doesn't recur
Gross description
- Polypoid or exophytic, rubbery, tan-brown, up to 4.9 cm but without destructive growth
Microscopic (histologic) description
- Proliferation of glandular spaces lined by ciliated epithelium or goblet cells
- Glands have thick, eosinophilic basement membranes
- Background resembles inflammatory polyp due to vascularization, edema and chronic inflammatory cells
Microscopic (histologic) images
Images hosted on other servers:
Numerous glands lined by
ciliated respiratory epithelium
(resembles inverted papilloma)
Each gland is surrounded by
an eosinophilic, thick
basement membrane
Contributed by Semir Vranić, M.D., Ph.D.
Various images
CK7
Differential diagnosis
- Adenocarcinoma: back to back glands, occasional nuclear pleomorphism, prominent mitotic activity, perineural invasion, desmoplastic stroma
- Inflammatory polyp: has fewer glands
- Inverted papilloma: usually on lateral nasal wall not nasal septum, usually hyperplastic squamous epithelium with only few goblet cells, thin basement membrane, no / rare mucoserous glands
