Nasal cavity, paranasal sinuses, nasopharynx
Other nonneoplastic lesions
Respiratory epithelial adenomatoid hamartoma

Topic Completed: 1 November 2004

Minor changes: 3 March 2020

Copyright: 2004-2020,, Inc.

PubMed Search: Respiratory epithelial adenomatoid hamartoma nasal

Nat Pernick, M.D.
Page views in 2019: 3,924
Page views in 2020 to date: 2,897
Cite this page: Pernick N. Respiratory epithelial adenomatoid hamartoma. website. Accessed September 18th, 2020.
Definition / general
  • First described in 1995
  • Usually posterior nasal septum of men
  • Median age 58 years (range 27 - 82 years)
  • Associated with chronic rhinosinusitis
  • Complete excision
  • Usually doesn't recur
Gross description
  • Polypoid or exophytic, rubbery, tan-brown, up to 4.9 cm but without destructive growth
Microscopic (histologic) description
  • Proliferation of glandular spaces lined by ciliated epithelium or goblet cells
  • Glands have thick, eosinophilic basement membranes
  • Background resembles inflammatory polyp due to vascularization, edema and chronic inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Numerous glands lined by
ciliated respiratory epithelium
(resembles inverted papilloma)

Each gland is surrounded by
an eosinophilic, thick
basement membrane

Contributed by Semir Vranić, M.D., Ph.D.

Various images


Differential diagnosis
  • Adenocarcinoma: back to back glands, occasional nuclear pleomorphism, prominent mitotic activity, perineural invasion, desmoplastic stroma
  • Inflammatory polyp: has fewer glands
  • Inverted papilloma: usually on lateral nasal wall not nasal septum, usually hyperplastic squamous epithelium with only few goblet cells, thin basement membrane, no / rare mucoserous glands
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