Nasal cavity, paranasal sinuses, nasopharynx
General
WHO classification
Authors: Abeer Salama, M.D., Bin Xu, M.D., Ph.D.
Editorial Board Member: Marc Pusztaszeri, M.D.
Deputy Editor-in-Chief: Kelly Magliocca, D.D.S., M.P.H.
Last author update: 8 April 2021
Last staff update: 22 October 2021
Copyright: 2020-2023, PathologyOutlines.com, Inc.
PubMed Search: WHO classification[TIAB] nasal[TIAB]
Table of Contents
Definition / general | Major updates | WHO (2017) nasal cavity, paranasal sinuses and skull base | WHO (2017) nasopharynx | Videos | Additional references | Board review style question #1 | Board review style answer #1Cite this page: Salama A, Xu B. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/nasalwhoclassification.html. Accessed September 25th, 2023.
Definition / general
- Classification is based on WHO classification of tumors of the nasal cavity, paranasal sinuses and skull base (4th edition, 2017)
Major updates
- Several new entities and provisional entities were added to the chapter of nasal cavity, paranasal sinuses and skull base, including:
- HPV related multiphenotypic sinonasal carcinoma
- SMARCB1 deficient sinonasal carcinoma
- Renal cell-like adenocarcinoma
- Seromucinous hamartoma
- NUT carcinoma
- Biphenotypic sinonasal sarcoma
WHO (2017) nasal cavity, paranasal sinuses and skull base
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Carcinomas ICD-O codes
- Keratinizing squamous cell carcinoma 8071/3
- Nonkeratinizing squamous cell carcinoma 8072/3
- Provisional entity: HPV related multiphenotypic sinonasal carcinoma
- Spindle cell squamous cell carcinoma 8074/3
- Lymphoepithelial carcinoma 8082/3
- Sinonasal undifferentiated carcinoma 8020/3
- Provisional entity: SMARCB1 deficient sinonasal carcinoma
- NUT carcinoma 8023/3
- Neuroendocrine carcinoma
- Small cell neuroendocrine carcinoma 8041/3
- Large cell neuroendocrine carcinoma 8013/3
- Adenocarcinoma
- Intestinal type adenocarcinoma 8144/3
- Nonintestinal type adenocarcinoma 8140/3
- Provisional entity: renal cell-like adenocarcinoma
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Teratocarcinosarcoma 9081/3
Sinonasal papillomas ICD-O codes
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Respiratory epithelial lesions
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Salivary gland tumors ICD-O codes
- Pleomorphic adenoma 8940/0
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Malignant soft tissue tumors ICD-O codes
- Fibrosarcoma 8810/3
- Undifferentiated pleomorphic sarcoma 8802/3
- Leiomyosarcoma 8890/3
- Rhabdomyosarcoma, NOS 8900/3
- Embryonal rhabdomyosarcoma 8910/3
- Alveolar rhabdomyosarcoma 8920/3
- Pleomorphic rhabdomyosarcoma, adult type 8901/3
- Spindle cell rhabdomyosarcoma 8912/3
- Angiosarcoma 9120/3
- Malignant peripheral nerve sheath tumor 9540/3
- Biphenotypic sinonasal sarcoma
- Synovial sarcoma 9040/3
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Borderline / low grade malignant soft tissue tumors ICD-O codes
- Desmoid type fibromatosis 8821/1
- Sinonasal glomangiopericytoma 9150/1
- Solitary fibrous tumor 8815/1
- Epithelioid hemangioendothelioma 9133/3
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Benign soft tissue tumors ICD-O codes
- Leiomyoma 8890/0
- Hemangioma 9120/0
- Schwannoma 9560/0
- Neurofibroma 9540/0
- Meningioma 9530/0
- Sinonasal ameloblastoma 9310/0
- Chondromesenchymal hamartoma
- Extranodal NK / T cell lymphoma 9719/3
- Extraosseous plasmacytoma 9734/3
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Other tumors ICD-O codes
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Hematolymphoid tumors ICD-O codes
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Neuroectodermal / melanocytic tumors ICD-O codes
WHO (2017) nasopharynx
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Nasopharyngeal carcinoma ICD-O codes
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Salivary gland tumors ICD-O codes
- Adenoid cystic carcinoma 8200/3
- Salivary gland anlage tumor
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Benign and borderline lesions ICD-O codes
- Hairy polyp
- Ectopic pituitary adenoma 8272/0
- Craniopharyngioma 9350/1
-
Soft tissue tumors ICD-O codes
- Nasopharyngeal angiofibroma 9160/0
-
Hematolymphoid tumors ICD-O codes
- Diffuse large B cell lymphoma 9680/3
- Extraosseous plasmacytoma 9734/3
- Extramedullary myeloid sarcoma 9930/3
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Notochord tumors ICD-O codes
- Chordoma 9370/3
Videos
WHO's new in sinonasal tract pathology
Dr. Thompson
Additional references
Board review style question #1
What are the three subtypes of nasopharyngeal carcinoma in the WHO classification?
- Keratinizing, nonkeratinizing, basaloid
- Keratinizing, nonkeratinizing, neuroendocrine carcinoma
- Keratinizing, nonkeratinizing, nasopharyngeal papillary adenocarcinoma
- Keratinizing, nonkeratinizing, HPV-positive
Board review style answer #1
