Nasal cavity, paranasal sinuses, nasopharynx


WHO classification

Editorial Board Member: Marc Pusztaszeri, M.D.
Deputy Editor-in-Chief: Kelly Magliocca, D.D.S., M.P.H.
Abeer Salama, M.D.
Bin Xu, M.D., Ph.D.

Topic Completed: 8 April 2021

Minor changes: 22 October 2021

Copyright: 2020-2021,, Inc.

PubMed Search: WHO classification[TIAB] nasal[TIAB]

Abeer Salama, M.D.
Bin Xu, M.D., Ph.D.
Page views in 2020: 96
Page views in 2021 to date: 1,508
Cite this page: Salama A, Xu B. WHO classification. website. Accessed December 2nd, 2021.
Definition / general
  • Classification is based on WHO classification of tumors of the nasal cavity, paranasal sinuses and skull base (4th edition, 2017)
Major updates
  • Several new entities and provisional entities were added to the chapter of nasal cavity, paranasal sinuses and skull base, including:
    • HPV related multiphenotypic sinonasal carcinoma
    • SMARCB1 deficient sinonasal carcinoma
    • Renal cell-like adenocarcinoma
    • Seromucinous hamartoma
    • NUT carcinoma
    • Biphenotypic sinonasal sarcoma
WHO (2017) nasal cavity, paranasal sinuses and skull base

WHO (2017) nasopharynx

    Benign and borderline lesions ICD-O codes
  • Hairy polyp
  • Ectopic pituitary adenoma 8272/0
  • Craniopharyngioma 9350/1

    Notochord tumors ICD-O codes
  • Chordoma 9370/3

WHO's new in sinonasal tract pathology
Dr. Thompson

Board review style question #1
What are the three subtypes of nasopharyngeal carcinoma in the WHO classification?

  1. Keratinizing, nonkeratinizing, basaloid
  2. Keratinizing, nonkeratinizing, neuroendocrine carcinoma
  3. Keratinizing, nonkeratinizing, nasopharyngeal papillary adenocarcinoma
  4. Keratinizing, nonkeratinizing, HPV-positive
Board review style answer #1
A. Keratinizing, nonkeratinizing, basaloid

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Reference: WHO classification
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