Oral cavity & oropharynx

Inflammatory / immune mediated (noninfectious)

Melkersson-Rosenthal syndrome

Topic Completed: 1 March 2013

Minor changes: 30 December 2020

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PubMed Search: Melkersson-Rosenthal syndrome oral cavity

Charu Thakral, M.D.
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Cite this page: Thakral C. Melkersson-Rosenthal syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityMRsyndrome.html. Accessed December 8th, 2021.
Definition / general
  • Rare neurological disorder characterized by orofacial swelling (usually of upper lip), peripheral facial nerve paralysis and plicated tongue
  • No known cause; onset in childhood or early adolescence
  • After recurrent attacks, swelling may persist and eventually become permanent
  • Lips become hard, cracked and fissured with a reddish brown discoloration
  • Cheilitis granulomatosa: may be a variant, sometimes considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome
Case reports
  • Symptomatic
Clinical images

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Diffuse swelling of lip

Microscopic (histologic) description
  • Granulomatous inflammation of lip stroma
Microscopic (histologic) images

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Nonnecrotizing granulomas

Giganto-epithelioid granuloma

Differential diagnosis
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