Table of Contents
Definition / general | Terminology | Epidemiology | Sites | Etiology | Clinical features | Prognostic factors | Case reports | Treatment | Gross description | Microscopic (histologic) description | Differential diagnosisCite this page: Fernandez NC. Adenomatoid hyperplasia of minor glands. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityadenomatoidhyperplasia.html. Accessed March 28th, 2024.
Definition / general
- Uncommon benign entity first described in 1971 (Oral Surg Oral Med Oral Pathol 1991;71:583)
Terminology
- Also called acinar adenomatoid hyperplasia (Barnes: Surgical Pathology of the Head and Neck, 3rd Edition, 2008 [p500])
Epidemiology
- Most cases reported in Caucasians, uncommon in Asians (Barnes: Surgical Pathology of the Head and Neck, 3rd Edition, 2008 [p500])
- Ages 9 to 79 years; 58% male (Oral Surg Oral Med Oral Pathol 1991;71:583)
Sites
- 80% on hard and soft palate
Etiology
- Chronic, local trauma (smokers, denture wearers) may be contributing factor (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:482)
Clinical features
- Presents as painless, sessile swelling at junction of hard and soft palate; may mimic a salivary gland tumor (Barnes: Surgical Pathology of the Head and Neck, 3rd Edition, 2008 [p500])
Prognostic factors
- Does not appear to predispose to benign or malignant salivary gland neoplasia
Case reports
- 48 year old Asian man with painless swelling in palate (J Laryngol Otol 1996;110:167)
Treatment
- Excision is curative (Barnes: Surgical Pathology of the Head and Neck, 3rd Edition, 2008 [p500])
Gross description
- Localized swelling resembling a neoplasm, 0.5 - 2.7 cm
Microscopic (histologic) description
- Multiple aggregates, varying in size, of normal appearing mucous acini surrounded by fibrous connective tissue stroma
- Normal ductal structures
- Overlying palatal epithelium is usually normal but may have lichenoid reaction or pseudoepitheliomatous hyperplasia
- Occasionally, areas of interstitial mucous extravasation with associated inflammatory reaction (Barnes: Surgical Pathology of the Head and Neck, 3rd Edition, 2008 [p500]) but typically no significant inflammatory cell infiltrates (Oral Surg Oral Med Oral Pathol 1991;71:583)
Differential diagnosis
- Idiopathic hyperplasia of the sublingual gland or "pouting" sublingual glands is seen as an enlargement in the floor of the mouth in totally or partially edentulous patients; sublingual glands may be otherwise normal or show nonspecific chronic inflammation