Oral cavity & oropharynx

Oral cavity squamous cell carcinoma


Last author update: 1 November 2013
Last staff update: 1 April 2021

Copyright: 2002-2023, PathologyOutlines.com, Inc.

PubMed Search: Basaloid squamous cell carcinoma[TI] oral

Nat Pernick, M.D.
Page views in 2022: 3,325
Page views in 2023 to date: 1,687
Cite this page: Pernick N. Basaloid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavitybasaloidscc.html. Accessed May 31st, 2023.
Definition / general
  • Uncommon, < 200 cases reported
  • Median age 62 years (range 27 - 88 years), 88% male, 92% smokers and 88% drinkers
  • Sites: base of tongue, tonsil, hypopharynx; also other sites outside upper aerodigestive tract
  • Aggressive with 68% having regional metastases at presentation, 77% stage III / IV, median survival 18 months
  • Metastases to lung
Case reports
  • Radical surgery, radiation therapy or chemotherapy
Microscopic (histologic) description
  • Lobules, nests or cribriform patterns of small basaloid cells with peripheral palisading and a thick basement membrane
  • Cells have minimal cytoplasm, are moderately pleomorphic with hyperchromatic nuclei and often abrupt transition to squamous epithelium
  • Single cell necrosis and comedonecrosis are common; often contiguous with carcinoma in situ in surface epithelium
  • Frequent mitotic activity, stroma often hyalinized or myxoid; variable pseudoglandular spaces resembling adenoid cystic carcinoma
  • Rarely has spindle cell component (Arch Pathol Lab Med 1995;119:181)
Positive stains
Differential diagnosis
Back to top
Image 01 Image 02