Oral cavity & oropharynx

Other nonneoplastic


Topic Completed: 1 April 2013

Minor changes: 12 October 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Ephelis oral cavity[TIAB]

Charu Thakral, M.D.
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Cite this page: Thakral C. Ephelis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityephelis.html. Accessed December 8th, 2021.
Definition / general
  • Also called freckle
  • Solitary melanotic macules, usually of lower lip
  • More common in women; associated with Peutz-Jeghers syndrome
Case reports
Clinical images

Images hosted on other servers:

55 year old woman

60 year old man

26 year old woman

37 year old woman

Microscopic (histologic) description
  • Hyperpigmentation of basal layer with elongation of rete ridges
Microscopic (histologic) images

Images hosted on other servers:

Keratinocytes (fig d)

Differential diagnosis
  • Melanoacanthoma: melanocytes mixed with keratinocytes
  • Melanosis: pigmented patches in hard palate or gingiva
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