Oral cavity & oropharynx

Soft tissue tumors & proliferations

Congenital epulis of newborn

Topic Completed: 1 January 2013

Minor changes: 4 August 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Epulis[TI] oral cavity[mh]

Charu Thakral, M.D.
Page views in 2020: 3,120
Page views in 2021 to date: 4,184
Cite this page: Thakral C. Congenital epulis of newborn. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityepulis.html. Accessed December 7th, 2021.
Definition / general
  • Congenital granular cell tumor of alveolar mucosa of jaw in newborns
  • 90% girls; 10% present as multiple lesions
  • Doesn't recur, even if incompletely excised
  • 0.5 - 2 cm soft, pedunculated mucosal mass
  • Spontaneously regresses over first 8 months of life (Am J Surg Pathol 1981;5:37)
  • Congenital granular cell myoblastoma, granular cell epulis of infancy and granular cell fibroblastoma
  • Exclusively on anterior alveolar ridge of maxilla and mandible, usually overlying future canine and lateral incisor teeth
Case reports
Clinical images

Contributed by Dhiraj B. Nikumbh, M.B.B.S., M.D.

2 day old girl with
difficulty eating and
breathing due to
upper jaw lesion

Images hosted on other servers:

Lesion at 3 weeks

Lesion at 16 months

Tumor arising from anterior maxillary alveolus

Mass protruding from mouth

Gross images

Contributed by Dhiraj B. Nikumbh, M.B.B.S., M.D.

Congenital granular cell tumor

Images hosted on other servers:

Homogenous appearance

Microscopic (histologic) description
  • Confluent to nodular submucosal growth of tumors composed of large polygonal cells with eosinophilic granular cytoplasm and small central nuclei
  • Overlying epithelium is atrophic; does NOT show pseudoepitheliomatous hyperplasia (common with granular cell tumor of adults)
Microscopic (histologic) images

Contributed by Dhiraj B. Nikumbh, M.B.B.S., M.D.

Stratified squamous epithelium

Abundant granular eosinophilic cytoplasm


Images hosted on other servers:

Polygonal cells with granular cytoplasm and small round nuclei

Meshwork of delicate blood vessels

Positive stains
Negative stains
  • S100 (in contrast to granular cell tumor of adults), laminin, Leu7, NSE
Electron microscopy images

Images hosted on other servers:

Granules and lysosomes

Differential diagnosis
Back to top
Image 01 Image 02