Table of ContentsDefinition / general | Case reports | Clinical images | Microscopic (histologic) description
Cite this page: Thakral C. Erythema multiforme. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityerythemamultiforme.html. Accessed December 8th, 2021.
Definition / general
- Part of spectrum of reactive mucocutaneous disorders with maculopapular vesiculobulbous eruptions that includes erythema multiforme (EM - minor and major), Stevens-Johnson syndrome (SJS, if more mucosal involvement and epidermal necrosis) and toxic epidermal necrolysis (TEN)
- Due to cancer, collagen vascular disorder, drugs, infection
- Oral erythema multiforme: variant with only oral lesions and no skin involvement
Microscopic (histologic) description
- Necrotic keratinocytes, spongiosis, basal layer liquefaction, dermal edema, perivascular or interface lymphocytes