Oral cavity & oropharynx
Infectious mononucleosis

Topic Completed: 1 August 2012

Minor changes: 12 October 2020

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PubMed Search: Infectious mononucleosis oral cavity

Patricia DeVilliers D.D.S., M.S.
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Cite this page: DeVilliers P. Infectious mononucleosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavitymono.html. Accessed April 18th, 2021.
Definition / general
  • Acute pharyngitis and tonsillitis with gray-white exudate, lymphadenopathy in neck
  • Due to Epstein-Barr virus infection
Microscopic (histologic) description
  • Tonsil: reactive lymphoid hyperplasia (polymorphous transformed lymphocytes) with extensive immunoblastic proliferation in sheets and nodules, marked atypia resembling Reed-Sternberg cells (Am J Surg Pathol 1987;11:122)
Microscopic (histologic) images

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Peripheral blood lymphocytosis

Reactive lymphocytes

Negative stains
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