Oral cavity & oropharynx

Benign epithelial tumors & processes

Multifocal epithelial hyperplasia

Topic Completed: 1 May 2013

Minor changes: 13 October 2020

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PubMed Search: Multifocal epithelial hyperplasia[TIAB] oral cavity[mh]

Charu Thakral, M.D.
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Cite this page: Thakral C. Multifocal epithelial hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavitymultifocalepithelialhyperplasia.html. Accessed December 7th, 2021.
Definition / general
  • Also called Heck disease
  • Discrete, recurrent papillary lesions on oral mucosa in Native American and Eskimo children, associated with HPV 1, 13, 32 (Eur J Dermatol 2011;21:396)
Case reports
Clinical images

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Slightly elevated

Multiple lesions

Lesions on tongue and lip

Gross description
  • Well circumscribed, sessile and pale elevation of buccal mucosa
Microscopic (histologic) description
  • Balloon cells in Malpighian layers, localized areas of mucosal epithelial hyperplasia with marked acanthosis and parakeratosis
Microscopic (histologic) images

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Typical nuclear changes

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