Oral cavity & oropharynx

Salivary gland tumors & processes

Polymorphous adenocarcinoma

Topic Completed: 1 November 2013

Minor changes: 25 June 2021

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PubMed Search: Polymorphous low grade adenocarcinoma[TI] minor salivary glands

Nat Pernick, M.D.
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Cite this page: Pernick N. Polymorphous adenocarcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityplga.html. Accessed December 8th, 2021.
Definition / general
  • Usually palate; second most common tumor at this location after adenoid cystic carcinoma
  • Median age 54 years, range 22 - 71 years and 2/3 women
  • 30% recur, nodal metastases in 15%, 10% have distant metastases or tumor related death (Am J Surg Pathol 2000;24:1319)
Microscopic (histologic) description
  • Nonencapsulated
  • Uniform plump columnar cells with bland nuclei with diverse growth patterns (tubular, cribriform, papillary, solid, fascicular, microcystic, single file, pseudoadenoid cystic [without true lumens], strand-like, mixed)
  • Perineural invasion common around small nerves; infiltrative borders; up to 12 mitotic figures per 10 HPF; rare tumor necrosis
Positive stains
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