Granulomatous inflammation

Topic Completed: 1 August 2011

Minor changes: 5 May 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: "Granulomatous inflammation" ovary

Mohiedean Ghofrani, M.D.
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Cite this page: Ghofrani M. Granulomatous inflammation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarynontumorgranulomatous.html. Accessed August 6th, 2020.
Definition / general
  • Necrotizing or nonnecrotizing granulomatous inflammation of the ovary
  • Cortical granulomas are common incidental findings with uncertain clinical significance
  • Primary ovarian tuberculosis and other primary ovarian granulomas are uncommon
  • Frequency of secondary ovarian granulomas depends on primary cause
Clinical features
  • Often an incidental finding or part of a systemic granulomatous disorder
Case reports
  • In secondary cases, treat primary cause
Gross description
  • May present as a mass and simulate a tumor
Microscopic (histologic) description
  • Tuberculosis is typically confined to the cortex
Microscopic (histologic) images

AFIP images

Actinomycosis: ovary is replaced by tissue that was soft and yellow; characteristic sulfur granule surrounded by polymorphonuclear leukocytes is on the right

Actinomycosis: histiocytes have abundant bubbly gray pink cytoplasm and resemble signet ring cells

Actinomycosis: histiocytes are mucicarmine+

Contributed by Eman Abdelzaher, M.D., Ph.D.

Actinomycosis: tubo-ovarian

Images hosted on other servers:

Central suppuration
and surrounding
giant cells in
Crohn's disease


Positive stains
  • AFB is typically positive in tuberculous oophoritis
Additional references
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