Table of Contents
Definition / general | Epidemiology | Etiology | Clinical features | Prognostic factors | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Ghofrani M. Hyperreactio luteinalis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarynontumorhyperreactio.html. Accessed December 4th, 2024.
Definition / general
- Bilateral, ovarian enlargement due to multiple, luteinized follicle cysts
Epidemiology
- Rare
- Associated with hydatidiform mole, choriocarcinoma, fetal hydrops due to Rh sensitization and multiple gestations
- Rarely seen in uncomplicated, single pregnancy
Etiology
- Due to hCG stimulation or hypersensitivity to hCG
Clinical features
- Usually no symptoms, may have pain from hemorrhage; rarely ascites
- Virilization in 15% of mothers but not female infants in cases without gestational trophoblastic disease
Prognostic factors
- Only rarely recurs (J Clin Pathol 2005;58:439)
Case reports
- Associated with HELLP syndrome (Fertil Steril 2008;90:2008.e13)
- With hirsutism (Gynecol Endocrinol 2007;23:248)
- With marked virilization and hyperglycemia (Am J Perinatol 2006;23:85)
Treatment
- Cysts typically involute within 6 months (Arch Pathol Lab Med 1989;113:921)
- Operate only to remove infarcted tissue or to control hemorrhage
Gross description
- Multiple, bilateral thin walled cysts, filled with clear or hemorrhagic fluid
Microscopic (histologic) description
- Follicular cysts with luteinization of theca interna or granulosa cells, edema of theca layer and stroma