Other tumors


Topic Completed: 1 January 2014

Minor changes: 21 October 2020

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PubMed Search: Angiomyolipoma ovary

Nalini Gupta, M.D.
Page views in 2020: 793
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Cite this page: Gupta N. Angiomyolipoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumoraml.html. Accessed October 21st, 2021.
Definition / general
  • Benign tumor seen mostly in kidney
  • Composed of blood vessels, smooth muscle cells and fat cells (hence the name: angio-, myo- and lip-)
  • Two types: isolated angiomyolipoma and angiomyolipoma associated with tuberous sclerosis
  • Mostly in kidney
  • Rarely in other organs such as liver, colon, lung, heart, nasal cavity and oral cavity
Clinical features
  • Increasing heaviness and mild tenderness in the iliac fossa
  • Intratumoral or retroperitoneal hemorrhage
  • Scanning: ultrasound, CT and MRI
  • Final diagnosis is by histology and immunhistochemistry
Radiology description
  • USG shows echogenic appearance due to its fat content and the presence of multiple tissue interfaces within it (Radiology 1996;198:789)
Case reports
  • Complete surgical resection
Gross description
Microscopic (histologic) description
  • Typical case shows mixture of mature adipose tissue, tortuous thick walled blood vessels lacking elastic lamina and bundles of smooth muscle that seem to emanate from the vessel wall
Microscopic (histologic) images

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Clusters of adipocytes
(fig 1)

Adipocytes, blood vessels, smooth muscle bundles (fig 2)

Angiomyolipoma not ovary

Positive stains
  • CD117 (c-kit), progesterone receptor, desmin, actin, HMB45, vimentin
  • Also S100P
Flow cytometry description
  • Aneuploidy
  • Tuberous sclerosis may show mutation of TSC1 and TSC2 genes
Differential diagnosis
  • Oxyphilic tumors are HMB45 negative
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