Other tumors

Benign papillary mesothelioma

Topic Completed: 1 December 2014

Minor changes: 21 October 2020

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PubMed Search: Benign papillary mesothelioma ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Benign papillary mesothelioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorb9papmeso.html. Accessed October 16th, 2021.
Definition / general
  • Unusual variant of epithelial mesothelioma (JDMS 2013;6:1)
  • Occurs mainly in the peritoneum
  • Tumors of < 2 cm are considered benign while larger tumors are more likely to disseminate (J Gynecol Surg. 2013;29:59)
  • Peritoneum, pericardium, and tunica vaginalis
Clinical features
  • Adominal mass, pain
  • Ultrasonography shows an ovarian mass
Case reports
  • Salpingo-oophorectomy
  • Yellowish firm, multinodular ovarian mass
Gross description
  • Yellowish firm, multinodular ovarian mass
Microscopic (histologic) description
  • Thin fibrovascular papillae lined by relatively uniform cuboidal mesothelial cells
  • Psammoma bodies are occasionally encountered
Microscopic (histologic) images

Images hosted on other servers:

Well differentiated papillary mesothelium

Strongly positive for calretinin

Positive stains
Negative stains
Differential diagnosis
  • Diffuse malignant mesothelioma (DMM): cytological atypia, abnormal mitoses and bizarre cells
  • Reactive mesothelial hyperplasia
  • Serous papillary adenocarcinoma: CEA positive
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