Table of Contents
Definition / general | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stainsCite this page: Ehdaivand S. Borderline Brenner tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorborderlinebrenner.html. Accessed January 18th, 2021.
Definition / general
- Mean age 60 years, older than for benign Brenner tumor
- Larger tumor with mass related symptoms
- May be associated with bladder urothelial carcinoma
- Rare local recurrence, otherwise benign behavior
Gross description
- Unilateral, multilocular cysts, 10 - 25 cm with papillary or polypoid projection into lumen
Gross images
AFIP images
Polypoid mass
Microscopic (histologic) description
- Solid and papillary epithelial proliferation with moderate to high grade nuclear atypia
- Papillary areas lined by multilayer epithelium (looks like high grade urothelial carcinoma), cells have prominent nucleoli, nuclear grooves, no stromal invasion
Microscopic (histologic) images
AFIP images
Papillae protrude into lumen
Well-differentiated transitional cells
With high grade transitional cell carcinoma
Positive stains
Negative stains
- CK20
