Brenner tumors
Borderline Brenner tumor

Topic Completed: 1 December 2012

Minor changes: 19 October 2020

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PubMed Search: ovarian borderline Brenner tumor

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Cite this page: Ehdaivand S. Borderline Brenner tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorborderlinebrenner.html. Accessed January 18th, 2021.
Definition / general
  • Mean age 60 years, older than for benign Brenner tumor
  • Larger tumor with mass related symptoms
  • May be associated with bladder urothelial carcinoma
  • Rare local recurrence, otherwise benign behavior
Gross description
  • Unilateral, multilocular cysts, 10 - 25 cm with papillary or polypoid projection into lumen
Gross images

AFIP images

Polypoid mass

Microscopic (histologic) description
  • Solid and papillary epithelial proliferation with moderate to high grade nuclear atypia
  • Papillary areas lined by multilayer epithelium (looks like high grade urothelial carcinoma), cells have prominent nucleoli, nuclear grooves, no stromal invasion
Microscopic (histologic) images

AFIP images

Papillae protrude into lumen

Well-differentiated transitional cells

With high grade transitional cell carcinoma

Positive stains
Negative stains
  • CK20
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