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Topic Completed: 1 December 2014

Minor changes: 6 April 2021

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PubMed Search: Fibromatosis [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Fibromatosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorfibromatosis.html. Accessed October 21st, 2021.
Definition / general
  • First defined by Young and Scully in 1984 as tumorlike ovarian enlargement due to diffuse ovarian fibrosis, caused by nonneoplastic proliferation of undifferentiated ovarian stroma (Int J Gynecol Pathol 1984;3:153)
  • Abdominal or extraabdominal
  • Local tissue injury activates platelets and macrophages, which release growth factors that stimulates fibroblastic proliferation around follicle
  • May represent burnt out stage of massive ovarian edema (Surgical Pathology of the Ovaries - pgs. 147-54)
Clinical features
  • Menstrual abnormalities, abdominal pain
  • Rarely hirsutism or virilization
  • Normal: CA125, CEA, CA19-9, AFP
Radiology description
  • Ultrasonography: intrapelvic solid tumors including cystic areas
  • CT: hyperdense (to myometrium), homogenous, solid and variably enhancing solid ovarian mass
  • MRI: Hypointense lobulated ovarian masses (Gynecol Oncol 2004;94:223)
Case reports
  • Salpingo-oophorectomy
Clinical images

Images hosted on other servers:

Ovarian fibromatosis

Bilateral heterogeneously echogenic ovarian masses

Slightly hyperattenuating

Poor enhancement of masses

Low signal intensity

Bilateral adnexal masses

Gross description
  • Solid ovarian mass 8-14 cm in diameter
  • Cut surface is grey-white, solid
Gross images

Images hosted on other servers:

Left ovarian mass

Microscopic (histologic) description
  • Fibromatoid proliferation of collagen producing spindle cell with follicles entrapped within the lesion
Differential diagnosis
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