Ovary

Other tumors

Hepatoid carcinoma



Topic Completed: 1 March 2015

Minor changes: 5 April 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Hepatoid carcinoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Hepatoid carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorhepatoid.html. Accessed October 21st, 2021.
Definition / general
  • Carcinoma with hepatoid differentiation, initially described in 1987 by Isikura and Scully (Cancer 1987;60:2775)
  • Appears to derive from ovarian surface epithelium
  • Called "hepatoid" based on two criteria:
Epidemiology
Sites
  • Occurs at other sites including ampulla of Vater, bladder, colon, kidney, lung, ovary, pancreas, stomach, uterus
Clinical features
  • Presents as adnexal mass, often with progressive abdominal distension and lower abdominal pain
  • Highly aggressive, progresses rapidly with metastases in abdomen and occasionally to lungs, with a median survival of 2 years (Acta Obstet Gynecol Scand 2007;86:498)
Laboratory
  • High serum AFP and serum CA125
Radiology description
  • Solid-cystic unilateral or bilateral adnexal mass
Case reports
Treatment
  • Insufficient data regarding the optimal treatment, but surgery with ovarian-like cancer chemotherapy regimens, such as carboplatin and paclitaxel, is often used (Acta Obstet Gynecol Scand 2007;86:498)
Clinical images

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Two soft tissue masses

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Right adnexal mass (fig 1)

Gross description
Microscopic (histologic) description
  • Resembles hepatocellular carcinoma, with tumor cells arranged in sheets, nests or trabeculae
  • Cells have distinct borders, moderate to abundant eosinophilic cytoplasm, cytoplasmic PAS+ hyaline globules
Microscopic (histologic) images

AFIP images
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Abundant eosinophilic cytoplasm

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Hepatoid component (left)

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AFP+



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Sheets, nests and trabeculae

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Sinusoidal arrangement of vascular channels (fig 2)

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AFP+ (fig 4)

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AFP, p53, CK7, α inhibin

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HepPar1+ (fig 3)

Positive stains
Negative stains
Molecular / cytogenetics description
  • Albumin mRNA by in situ hybridization
Differential diagnosis
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