Mesenchymal tumors


Last author update: 1 December 2014
Last staff update: 23 August 2022

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PubMed Search: Leiomyosarcoma ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Leiomyosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorleiomyosarcoma.html. Accessed June 5th, 2023.
Definition / general
  • Rare tumor of teratomatous or nonteratomatous origin
  • "True" leiomyosarcoma if of nonteratomatous origin
  • Omentum, reteroperitoneum, mesentery
  • Arises from: malignant degeneration of ovarian leiomyoma; smooth muscle in blood vessel walls in cortical stroma and corpus luteum, muscular attachments of ovarian ligament, wolfian duct remnants, or totipotential ovarian mesenchyme; or from a teratoma
Clinical features
Prognostic factors
Case reports
  • Multimodality treatment: surgical debulking, postoperative radiotherapy or chemotherapy
  • FIGO staging and treatment of ovarian sarcoma is same as for epithelial ovarian carcinoma (Obstet Gynecol Surv 2007;62:480)
Gross description
  • Solitary, lobular, soft fleshy solid mass with hemorrhage and cystic degeneration
Microscopic (histologic) description
  • Usually 2 of 3: moderate / severe cytologic atypia, 10+ MF/10 HPF, tumor cell necrosis
  • Varies from well differentiated to highly pleomorphic sarcoma
Microscopic (histologic) images

AFIP images

Epithelioid tumor

Images hosted on other servers:

Pleomorphic tumor cells

H-Caldesmon, desmin and smooth muscle actin

Negative stains
Differential diagnosis
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