Sex cord stromal tumors

Lipid (steroid, lipoid) cell tumor

Topic Completed: 1 December 2012

Minor changes: 19 October 2020

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PubMed search: Ovarian lipid cell tumor

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Cite this page: Ehdaivand S Lipid (steroid, lipoid) cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorlipid.html. Accessed September 21st, 2021.
Definition / general
  • Any age, usually associated with virilizing syndrome (defeminization and amenorrhea)
  • Cells either lutein (theca / stroma), hilar (Leydig, with Reinke crystals) or adrenal cortical type
  • If Cushing syndrome present, tumor often called "adrenal cortical type"
  • Exact origin of tumor is unknown
  • May be biologically active or inactive
  • Malignant: 25%, usually large (7 cm or more), necrosis, hemorrhage, nuclear atypia, mitoses and may have peritoneal implants
Gross description
  • Usually unilateral, yellow / brown nodules separated by fibrous trabeculae
Microscopic (histologic) description
  • Large rounded or polyhedral cells with abundant eosinophilic or vacuolated cytoplasm
Positive stains
  • Fat stains on fresh / frozen tissue, vimentin (75%), keratin (50%) and actin (30%)
Electron microscopy description
  • Increased smooth endoplasmic reticulum, mitochondria have tubulovesicular cristae
Differential diagnosis
  • Tumors with secondary proliferation of steroid hormone-producing cells: stromal luteoma, luteinized granulosa cell tumor (usually juvenile), fibroma-thecoma, stromal Leydig cell tumor and proliferations at periphery of other tumors
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