Other tumors


Topic Completed: 1 December 2014

Minor changes: 4 March 2021

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PubMed Search: Mesothelioma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Mesothelioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumormesothelioma.html. Accessed October 21st, 2021.
Definition / general
  • Primary ovarian malignant mesotheliomas (POMM) are a rare, aggressive neoplasm of mesothelial cells, with poor prognosis
  • Patients usually present with widespread peritoneal tumor but occasionally involvement is limited to 1 - 2 ovaries
  • Needs to be differentiated from secondary ovarian involvement by peritoneal malignant mesothelioma
  • Median age 52 years, range 16 to 63 years
  • Peritoneum, pericardium, tunica vaginalis
  • Asbestos exposure, prior radiotherapy
Clinical features
Case reports
  • 50 year old woman with simultaneous occurrence of well differentiated papillary mesothelioma and endometrioid ovarian cancer (Gynecol Oncol Case Rep 2013;4:53)
  • Surgery with / without chemotherapy or radiotherapy
Gross description
  • 3 - 15 cm, usually bilateral
  • Solid with small cysts
Gross images

AFIP images

Solid mural nodule and tumor on cyst lining

Microscopic (histologic) description
  • Epithelial or biphasic tumor with papillary, tubular-glandular or solid patterns with features of malignancy
  • Tumor cells have moderate atypia and low mitotic rate
  • Stroma is hyalinized, occasionally with striking hyalinized cores and psammoma bodies
Microscopic (histologic) images

AFIP images

Solid and tubulopapillary patterns

Surface of ovary

Images hosted on other servers:

Well differentiated papillary tumor

Biphasic tumor


Positive stains
Negative stains
Differential diagnosis
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