Metastases to ovary

Cervical carcinoma metastatic to ovary

Last author update: 1 February 2016
Last staff update: 20 March 2023 (update in progress)

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PubMed Search: Cervical carcinoma [title] ovary

Nalini Gupta, M.D.
Carlos Parra-Herran, M.D.
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Cite this page: Gupta N, Parra-Herran C. Cervical carcinoma metastatic to ovary. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumormetastaticcervicalcarc.html. Accessed June 5th, 2023.
Definition / general
  • Risk also increases with tumor stage, ranging from 0% in stage IA squamous cell carcinomas to 9.8% in stage IIB adenocarcinomas (Gynecol Oncol 1987;28:255, Gynecol Oncol 2006;101:234)
  • Epidemiology
    • Mean age of presentation is 57.4 years for squamous cell carcinoma and 50.2 years for adenocarcinoma (Gynecol Oncol 1991;41:46)
    Clinical features
    Radiology description
    • USG: enlarged ovaries
    Prognostic factors
    • In patients with cervical cancer, ovarian preservation and transposition is recommended in:
      • Women 44 years old or younger with squamous cell carcinoma stage IB-II
      • Clinically normal ovaries and no history of breast cancer or family history of ovarian cancer (Gynecol Oncol 2001;82:312)
    • Oophorectomy is recommended in patients that do not fulfill these criteria, in particular those with adenocarcinoma or locally advanced tumors (Int J Gynaecol Obstet 2007;99:64)
    Gross description
    Gross images

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    Uterus, growth
    in cervix
    extending up to
    endocervical canal

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    Bisected uterus, cut surface ovary

    Microscopic (histologic) description
    • Squamous cell carcinoma:
    • Adenocarcinoma:
      • Malignant glandular proliferation with confluent glandular, cribriform and papillary architecture
      • Stromal invasion may be expansile or infiltrative (J Clin Pathol 2012;65:591)
      • Usual (endocervical) type:
        • Glandular epithelium with mucinous or endometrioid differentiation
        • Neoplastic cells have pleomorphic, hyperchromatic, round to elongated nuclei with stratification and conspicuous apical mitoses
      • Gastric type:
        • Neoplastic cells have columnar shape and granular eosinophilic apical cytoplasm
        • Nuclei are round in shape and display significant atypia and pleomorphism
      • Importantly, malignant areas usually coexist with regions showing a benign and borderline appearance (architectural and cytologic)
    Microscopic (histologic) images

    Contributed by Carlos Parra-Herran, M.D.

    Endocervical carcinoma primary

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    Foci of metastatic squamous cells, H&E

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    p63, CK5/6, CK7, CK20

    Cytology images

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    High grade SIL

    Negative stains
    Molecular / cytogenetics description
    • Detection of HPV ribonucleic acid by PCR or in situ hybridization is a reliable method to differentiate metastatic HPV related cervical carcinoma (squamous cell and usual type adenocarcinoma) from primary ovarian tumors and other secondary lesions (Int J Gynecol Pathol 2004;23:7)
    Differential diagnosis
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