Other tumors

Malignant mixed Müllerian tumor

Topic Completed: 1 December 2014

Minor changes: 22 October 2020

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PubMed Search: Malignant mixed Müllerian tumor [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Malignant mixed Müllerian tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumormmt.html. Accessed October 24th, 2021.
Definition / general
  • Aggressive tumor with malignant epithelial and sarcomatous components
  • Most common in postmenopausal, low parity women
  • Very poor prognosis; stage is best predictor and most patients present at advanced stage
  • Malignant mixed mesodermal tumor, MMMT
  • Mostly postmenopausal females, peaks in sixth decade
  • Uterus, cervix
Clinical features
  • Abdominal mass, pain, vaginal bleeding
  • Risk factors include advanced age, excess estrogen exposure, nulliparity, prior pelvic irradiation, tamoxifen use (Lancet 2000;356:881)
Radiology description
  • Pelvic ultrasound and CT: heterogeneous pelvic mass containing solid parts with/without ascites
Case reports
Gross description
  • Soft and fleshy mass, often with bleeding and necrosis
Gross images

Contributed by Mona Kandil, M.D., Ph.D.



Omental deposit

Microscopic (histologic) description
  • Malignant epithelial and sarcomatous elements
  • Sarcomatous element can be homologous (nonspecific malignant stroma) or heterologous (malignant elements of a different tissue type, particularly cartilage)
  • Often contains cytoplasmic hyaline droplets containing alpha-1-antitrypsin (Hum Pathol 1982;13:930)
  • Rarely trophoblastic tissue (Hum Pathol 1988;19:1235)
Microscopic (histologic) images

Contributed by Mona Kandil, M.D., Ph.D.

Malignant stroma

High grade malignant glands

Necrotic foci

High grade epithelial tumor cells and necrosis

High grade tumor cells with mitotic figures

Images hosted on other servers:

Rhabdomyosarcoma component

Positive stains
Negative stains
Differential diagnosis
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