Mucinous tumors
Mucinous cystadenoma / adenofibroma

Topic Completed: 1 July 2012

Minor changes: 7 June 2021

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PubMed Search: benign mucinous tumor

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Cite this page: Ehdaivand S. Mucinous cystadenoma / adenofibroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumormucinousbenign.html. Accessed June 20th, 2021.
Definition / general
  • Includes cystadenoma, cystadenofibroma and adenofibroma (rare)
  • Lesions are a spectrum of benign lesions with varying amounts of cysts, glands, and stroma - the distinction is arbitrary
  • 5% bilateral
  • Associations: carcinoid tumors in same ovary, dermoid cyst, Brenner tumor, endocervical adenocarcinoma; rarely with Zollinger-Ellison syndrome
Case reports
Gross description
  • Smooth surface with multiple cystic spaces, variable amounts of solid areas
  • Unilocular cysts are almost always benign
  • Filled with translucent viscous fluid
Gross images

AFIP images

Mucinous cystadenoma

Associated with dermoid cyst

Microscopic (histologic) description
  • Tall, columnar, nonciliated cells, basal nuclei, abundant intracellular mucin
  • Usually endocervical type; also intestinal type (picket fence architecture with Paneth cells) or mixed
  • Stroma may be fibrous or mimic ovarian stroma
  • Tumor may be hypercellular or luteinized, often with calcifications
  • May have microscopic rupture of cysts with inflammatory reaction including histocytes and necrosis
  • Small bland papillae may be present, and mild, focal cytologic atypia may be present
  • Adenofibroma: may have crowded glands with atypia (Am J Surg Pathol 1991;15:227)
Microscopic (histologic) images

AFIP images

Surface epithelial inclusion cyst

Mucinous adenofibroma

Mucinous cystic tumor

Luteinization of
stroma resulting
in virilization
during pregnancy

Mucinous cystadenoma

Positive stains
Differential diagnosis
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