Other tumors


Topic Completed: 1 March 2015

Minor changes: 28 June 2021

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PubMed Search: Myofibroblastoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Myofibroblastoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumormyofibro.html. Accessed October 21st, 2021.
Definition / general
  • Myogenic stromal tumor
  • At other sites, may be called atypical variant of leiomyoma
  • 22 year old woman in single case report from ovary
  • Also at sites along anatomic "milk-line" that extends from axilla to medial groin, including breast, soft tissue of abdomen, back, buttock, groin/inguinal region, cervix, vaginal wall
Radiology description
  • At other sites (ultrasound / USG): solid, well circumscribed, homogeneous, slightly hypoechoic mass (Virchows Arch 2002;440:249)
  • Local excision; does not recur
Gross description
  • Large mass up to 9.0 cm, entirely replacing ovary (in single case report)
Gross images

Images hosted on other servers:

Myofibroblastoma of buttock

Microscopic (histologic) description
  • Unencapsulated but well circumscribed
  • Bland spindled cells arranged into various patterns, similar to solitary fibrous tumor
  • Also unusual morphologic variants (with atypical cells, epithelioid, myxoid with or without atypical cells, lipomatous, deciduoid-like)
Negative stains
Electron microscopy description
  • Variable admixture of undifferentiated mesenchymal cells, fibroblasts, myofibroblasts and smooth muscle cells
  • Generally, myofibroblasts are represented by cells rich in organelles (rough endoplasmatic reticulum, Golgi complexes) and containing bundles of myofilaments forming focal densities (Pathol Res Pract 1999;195:1)
Molecular / cytogenetics description
Differential diagnosis
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