Other tumors

Neuroendocrine carcinoma (non small cell type)

Topic Completed: 1 December 2014

Minor changes: 28 June 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Neuroendocrine carcinoma (non small cell type). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorneuroendocrinecarcinoma.html. Accessed October 21st, 2021.
Definition / general
  • Neuroendocrine carcinoma (NEC) can be small cell (SCNEC) [hypercalcemic or pulmonary] or non small cell type (NSCNEC)
  • NSCNEC are rare and aggressive
  • Typically admixed with other surface epithelial and germ cell neoplasms
  • Tend to present at advanced stage and cause death within a mean of 17 months after diagnosis (Am J Surg Pathol 2007;31:774)
Clinical features
Radiology description
Prognostic factors
Case reports
  • Combination of surgical resection (TAHBSO) and etoposide / platinum chemotherapy has been employed (Gynecol Oncol 2011;122:190)
  • Patients with stage III / IV disease often die of disease
Gross description
  • Mostly unilateral, cystic or solid / cystic
  • Median 16 cm, range 5 to 26 cm (Am J Surg Pathol 2007;31:774)
  • Can be associated with other epithelial neoplasm - mucinous neoplasms, endometrioid carcinoma, mixed endometrioid and mucinous carcinoma, high grade carcinoma not otherwise specified
Gross images

Images hosted on other servers:

Bilateral ovarian masses

Microscopic (histologic) description
  • Solid pattern, nests or trabeculae of large or intermediate oval to round cells
  • Brisk mitotic activity, areas of necrosis and single cell necrosis also seen
Microscopic (histologic) images

AFIP images

Nests and trabeculae


Images hosted on other servers:

Prominent nucleoli

Synaptophysin, pan-cytokeratin, mucicarmine


Positive stains
Negative stains
Electron microscopy description
  • Neurosecretory granules
Differential diagnosis
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