Other tumors

Osteoclast-like giant cell tumor

Topic Completed: 1 December 2014

Minor changes: 22 October 2020

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PubMed Search: Osteoclast-like giant cell tumor of ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Osteoclast-like giant cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorosteoclastlike.html. Accessed October 21st, 2021.
Definition / general
  • Peculiar microscopic picture of round or spindle shaped mononucleated stromal cells admixed with multinucleated giant cells
  • Likely represents a reactive lesion of mesenchymal ovarian stromal cells stimulated by substances in associated tumor or cyst, with monocytic / macrophage origin (Cancer 1993;71:1751)
  • Mostly associated with mucinous cyst, rarely with serous / hemorrhagic cysts
  • Benign clinical course, without recurrence or metastasis (Histol Histopathol 1995;10:55)
Clinical features
  • Abdominal mass or pelvic pain
Radiology description
  • USG: solid cystic ovarian mass
Case reports
  • Surgical: salpingo-oophorectomy
Gross description
  • Well circumscribed firm mass, 1 - 4 cm
  • Cut surface is yellow with brown hemorrhage
  • Adjacent ovarian tissue may show unilocular / multilocular cyst
Microscopic (histologic) description
  • Diffuse, bland appearing osteoclast-like giant cells mixed with pleomorphic mononuclear cells
  • Hemorrhage, large areas of necrosis and frequent mitotic figures among mononuclear cells
  • Infiltrative border, vascular invasion
  • No cystic tumor, no epithelial component
Microscopic (histologic) images

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Kidney: osteoclast-like giant cell tumor

Positive stains
  • Osteoclast-like giant cells: CD68, vimentin, alpha-1-antichymotrypsin and CD45
  • Mononuclear cells: vimentin, PCNA, actin
Negative stains
  • Mononuclear cells: keratin, EMA, CK7, CD45, CD68, S100
  • Osteoclastic giant cells: actin
Electron microscopy description
  • Giant cells have ruffled border and abundant mitochondria (resemble osteoclasts)
Differential diagnosis
  • Spindle cell mural nodule: no bone trabeculae; giant cells are keratin positive
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