Other tumors

Squamous cell carcinoma

Topic Completed: 1 June 2014

Minor changes: 22 October 2020

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PubMed Search: Squamous cell carcinoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Squamous cell carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorscc.html. Accessed October 21st, 2021.
Definition / general
  • Squamous cell carcinoma of ovary can be pure arising denovo or may represent extreme expression of squamous metaplasia in endometriosis, endometrioid carcinomas, transformation of ovarian teratomas and HPV related transformation
  • Pure SCC and those arising from endometriosis are included in surface epithelial tumor by WHO Classification
  • Often associated with dermoid cyst (50%) and endometriosis (20%)
  • SCC arising in dermoid are included in germ cell tumor by WHO (Am J Surg Pathol 1996;20:823)
  • SCCD (associated with dermoid ): 21 - 75 (mean, 52) years old
  • SCCE (associated with endometriosis ): 29 - 70 (mean, 49) years old
  • SCCP (Pure SCC): 27 - 73 (mean, 56) years old (Am J Surg Pathol 1996;20:823)
  • Genital and extragenital SCC
Clinical features
  • Lower abdominal mass
  • Final diagnosis is by histology
Radiology description
Prognostic factors
Case reports
  • Total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy, with additional steps as needed to ensure surgical debulking of all grossly visible disease
  • Role of adjuvant chemo and radiotherapy debatable
  • Few case report noted a response to early pa-clitaxel in combination with a platinum agent (Gynecol Oncol 2000;79:515)
Clinical images

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Triple tissular mass

Gross description
  • 6 - 35 cm
  • Often forming mural nodules with intracavitary protrusion
  • Focal necrosis and hemorrhage
Gross images

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Gross appearance of tumor

Microscopic (histologic) description
  • Can be well to poorly differentiated
  • Well differentiated form, SCC will show squamous maturation, keratin formation and intracellular bridging
  • Poorly differentiated form, few normal squamous features may be identifiable
Microscopic (histologic) images

AFIP images
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Centrally necrotic cells

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SCC in situ

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H&E, moderately differentiated SCC

Positive stains
  • MA903, p63 and CK5 / 6
Negative stains
  • CA 125
Differential diagnosis
  • Metastatic SCC: primary elsewhere especially cervix
  • Squamous metaplasia in endometrioid carcinoma: absence of malignant features
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