Ovary
Other tumors
Sebaceous adenoma
Author: Nalini Gupta, M.D.
Topic Completed: 1 March 2015
Minor changes: 22 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Sebaceous adenoma [title]
Table of Contents
Definition / general | Prognostic factors | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Gupta N. Sebaceous adenoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorsebaceousadenoma.html. Accessed October 21st, 2021.
Definition / general
- Benign sebaceous tumor, usually on head and neck (Pathology 1987;19:204), often associated with Muir-Torre syndrome
- Single case is reported in ovary arising within an ovarian mature cystic teratoma in a patient with Muir-Torre syndrome (Ann Diagn Pathol 2012;16:485), an autosomal dominant disorder characterized by neoplasms of skin (sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma or keratoacanthoma) and a GI / GU / gyn malignancy (eMedicine)
Prognostic factors
- Complete excision is curative
Microscopic (histologic) description
- Incompletely differentiated sebaceous lobules, irregular in size and shape
- Undifferentiated basaloid cells peripherally and mature sebaceous cells centrally
Microscopic (histologic) images
AFIP images
Maturation
Images hosted on other servers:
Low mag
Intermediate mag
High mag
Very high mag
Positive stains
- EMA
- Basaloid cell are positive for CK7 (Br J Dermatol 2007;156:378, J Am Acad Dermatol 1996;34:735)
Negative stains
Differential diagnosis
- Sebaceous hyperplasia: < 5 mm; associated with hair follicles
- Sebaceoma: basaloid cells predominate over mature sebocytes
