Table of Contents
Definition / general | Case reports | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Cytology images | Videos | Differential diagnosisCite this page: Ehdaivand S. Serous cystadenoma / adenofibroma / surface papilloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorserousbenign.html. Accessed April 15th, 2021.
Definition / general
- Includes cystadenoma, cystadenofibroma, adenofibroma, papillary cystadenoma, papillary cystadenofibroma, papillary adenofibroma
- The term used depends on the relative amount of fibrous stroma, but distinctions are often arbitrary
- Benign; 10-20% bilateral; most are partially or completely cystic; > 1 cm in size (< 1 cm signifies a cortical inclusion cyst or endosalpingiosis)
Case reports
- 11 year old girl with morbid obesity and giant serous cystadenoma arising from accessory ovary (J Med Case Rep 2008;2:7)
- 48 year old woman with serous cystadenoma with mural nodules of genital rhabdomyoma (Hum Pathol 2005;36:433)
Gross description
- Papillary tumors have papillary projections on outer surface or protruding into cystic cavity
- Cystadenoma: Usually 3-10 cm, oval to round, smooth glistening surface; usually watery clear to pale yellow cyst fluid, but can be viscous and mucoid
- Cystadenofibroma: varies from solid areas with knobby papillae to confluent firm areas
- Adenofibroma: entirely solid appearing; if surface papillary projections are prominent, designate as surface papillary serous adenofibroma
Gross images
AFIP images
Lining of a thin walled cyst is smooth and glistening
Serous papillary cystadenoma
Images hosted on other servers:
Serous cystadenoma
Cystadenofibroma
Microscopic (histologic) description
- Usually small, uni- to multi-locular cysts lined by a single layer of tall, columnar, ciliated cells resembling normal tubal epithelium or cuboidal non-ciliated epithelium resembling ovarian surface epithelium
- Stroma contains spindly fibroblasts
- If papillae are present, they are simple papillary processes
- No atypia, no architectural complexity, no invasion
- Adenofibromas and cystadenofibromas are composed predominantly of fibrous stroma, with glands and cysts forming a minor component
Microscopic (histologic) images
AFIP images
Cyst lined by
ciliated epithelium
Serous cystadenoma, low power
Adenofibroma
Images hosted on other servers:
Lining of simple cuboidal epithelium
Giant serous cystadenoma from accessory ovary
Adenofibroma
Cytology images
Images hosted on other servers:
Small epithelial cell cluster
Epithelium is CD68- but macrophages are CD68+
Videos
Histopathology Ovary - Serous cystadenoma
Differential diagnosis
- Rete cystadenoma: located in ovarian hilus, undulating epithelium, smooth muscle wall
