Other ovarian specific tumors

Small cell carcinoma of ovary, pulmonary type

Topic Completed: 1 December 2008

Minor changes: 21 October 2020

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PubMed Search: small cell carcinoma of ovary pulmonary type

Nat Pernick, M.D.
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Cite this page: Pernick N. Small cell carcinoma of ovary, pulmonary type. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorsmallcellpulmonary.html. Accessed October 20th, 2021.
Definition / general
  • Mean age 59 years (range 28-85 years)
  • Resembles conventional pulmonary small cell carcinoma
  • Poor prognosis
Case reports
Gross description
  • 50% bilateral, most have extraovarian spread at diagnosis, mean 13 cm (4-26 cm) and solid with variable cysts
Microscopic (histologic) description
  • Sheets and nests of small / medium size round / spindle cells with hyperchromatic nuclei, fine regular chromatin (not clumped), inconspicuous nucleoli and minimal cytoplasm
  • Also crush artifact, Azzopardi effect; occasionally associated with endometrioid carcinoma; may have squamous, mucinous and Brenner differentiation
Microscopic (histologic) images

AFIP images

Large nests of small cells are centrally necrotic

Scanty cytoplasm and hyperchromatic nuclei

Positive stains
  • Keratin, EMA, neuron specific enolase; occasional chromogranin
Negative stains
  • Vimentin
Electron microscopy description
  • Neurosecretory granules
Molecular / cytogenetics description
  • Aneuploid
Additional references
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