Graft versus host disease

Topic Completed: 1 August 2012

Minor changes: 13 July 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Graft versus host disease GVHD pancreas

Deepali Jain, M.D.
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Cite this page: Jain D. Graft versus host disease. website. Accessed August 6th, 2020.
Definition / general
  • Identified in autopsies of children with congenital immune deficiencies with GVHD of other organs (Hum Pathol 1994;25:908)
  • To diagnose, must pay careful attention to pancreatic ducts
  • Note: GVHD may occur post pancreas transplant, involving skin and other organs (Transplantation 2006;82:127)
Microscopic (histologic) description
  • Lymphocytes around large to medium ducts, damage to ductal epithelium (focal necrosis, reactive nuclear changes, inspissated secretions in duct lumens) and periductal edema (Histopathology 1989;14:121)
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