Eosinophilic pancreatitis

Topic Completed: 1 August 2012

Minor changes: 6 March 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Eosinophilic pancreatitis[TIAB]

Deepali Jain, M.D.
Page views in 2019: 305
Page views in 2020 to date: 237
Cite this page: Jain D. Eosinophilic pancreatitis. website. Accessed August 3rd, 2020.
Definition / general
  • Very rare (< 20 cases reported)
  • Usually peripheral eosinophilia and multiorgan involvement (Am J Surg Pathol 2003;27:334)
  • May have elevated serum IgE
  • May have hypereosinophilic syndrome: eosinophil count > 1500 cells/mm3 sustained over ≥ 6 months, history of allergic manifestations such as rhinitis and bronchial asthma, involvement of other organ systems such as skin, heart, GI tract, no other recognizable cause for eosinophilia, including parasitic infections and leukemia
  • May present as a pancreatic mass or common bile duct obstruction simulating malignancy
Case reports
Microscopic (histologic) description
  • Diffuse periductal, acinar and septal eosinophilic infiltrate affecting arteries and veins or clusters of eosinophils associated with pseudocysts
  • Also fibrosis
Microscopic (histologic) images

Images hosted on other servers:

14 year old boy: images from pancreas, duodenum, lymph node

Stillborn fetus (34 weeks) with anencephaly and diabetic mother

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