Exocrine tumors / carcinomas
Medullary carcinoma

Topic Completed: 1 August 2012

Minor changes: 9 March 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Medullary carcinoma pancreas

Deepali Jain, M.D.
Page views in 2019: 1,129
Page views in 2020 to date: 718
Cite this page: Jain D. Medullary carcinoma. website. Accessed August 11th, 2020.
Definition / general
Gross description
  • Soft (since minimal desmoplastic stroma)
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on other servers:

Various images

A: extensive necrosis;
B: poorly differentiated
tumor with syncytial
growth pattern

A: nuclear staining for MLH1;
B: loss of expression of MSH2;
C: loss of expression of MSH6

Molecular / cytogenetics description
  • Usually no KRAS mutations but 20% have inactivation of DNA mismatch repair system
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