Penis & scrotum
General
WHO classification
Author: Debra L. Zynger, M.D.
Editorial Board Member: Bonnie Choy, M.D.
Deputy Editor-in-Chief: Maria Tretiakova, M.D., Ph.D.
Last author update: 3 January 2023
Last staff update: 24 January 2024
Copyright: 2022, PathologyOutlines.com, Inc.
PubMed Search: Penis & scrotum WHO classification
Table of Contents
Definition / general | Major updates | WHO classification 2022 (ICD-O morphology terms if different) | Additional references | Board review style question #1 | Board review style answer #1Cite this page: Zynger DL. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/penisscrotumWHO.html. Accessed April 18th, 2024.
Definition / general
- WHO classification of tumors of the urinary and male genital tumors
- Currently on 5th edition, published in 2022
Major updates
- Terminology for squamous cell carcinoma groupings has been changed from non-HPV related to HPV independent and from HPV related to HPV associated
- Papillary basaloid carcinoma, warty basaloid carcinoma, pseudohyperplastic carcinoma, pseudoglandular carcinoma, carcinoma cuniculatum and mixed squamous cell carcinoma have been removed as distinct subtypes
- Pseudohyperplastic and pseudoglandular patterns are now a part of squamous cell carcinoma, usual type
- Carcinoma cuniculatum pattern is now a part of verrucous carcinoma
WHO classification 2022 (ICD-O morphology terms if different)
-
Benign and precursor squamous lesions
- Condyloma acuminatum
- Squamous cell carcinoma precursors, HPV associated
- Squamous cell carcinoma precursors, HPV independent
- Invasive squamous epithelial tumors
- HPV associated squamous cell carcinoma (squamous cell carcinoma, HPV associated)
- Basaloid squamous cell carcinoma
- Warty carcinoma
- Clear cell squamous cell carcinoma
- Lymphoepithelioma-like carcinoma (lymphoepithelial carcinoma)
- HPV independent squamous cell carcinoma (squamous cell carcinoma, HPV independent)
- Squamous cell carcinoma NOS (squamous cell carcinoma, NOS)
- HPV associated squamous cell carcinoma (squamous cell carcinoma, HPV associated)
- Other epithelial tumors
- Penile adenosquamous carcinoma (adenosquamous carcinoma)
- Penile mucoepidermoid carcinoma (mucoepidermoid carcinoma)
- Extramammary Paget disease (Paget disease, extramammary)
-
Invasive epithelial tumors of the penis and scrotum
-
Other scrotal tumors
Additional references
Board review style question #1
Which marker is utilized in the classification scheme of penile squamous cell carcinoma?
- ALK
- HPV
- PTEN
- TFEB
- TFE3
Board review style answer #1
