Penis & scrotum

Squamous cell carcinoma and variants

HPV associated squamous cell carcinoma

Clear cell carcinoma

Last author update: 1 April 2010
Last staff update: 28 October 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Clear cell carcinoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
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Cite this page: Chaux A, Cubilla AL. Clear cell carcinoma. website. Accessed May 30th, 2023.
Definition / general
  • Recently described aggressive variant of penile carcinoma
  • Middle aged men
  • Foreskin inner mucosa
  • Most likely of sweat gland origin
  • HPV 16 DNA found in all reported cases
Clinical features
  • All reported patients presented with inguinal nodal metastases with clear cells and sclerotic basement membrane material
Case reports
  • Excision with wide surgical margin
Gross description
  • Large, exophytic and partially ulcerated
  • Size 2.5 - 5.5 cm
Microscopic (histologic) description
  • Solid proliferation of large neoplastic clear cells
  • Marked nuclear atypia
  • Extensive geographical necrosis
  • Angiolymphatic invasion is common
  • Warty PeIN may be found at surface
Positive stains
Differential diagnosis
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