Penis & scrotum

Squamous cell carcinoma and variants

Clear cell carcinoma

Topic Completed: 1 April 2010

Minor changes: 28 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Clear cell carcinoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2020: 689
Page views in 2021 to date: 540
Cite this page: Chaux A, Cubilla AL. Clear cell carcinoma. website. Accessed October 25th, 2021.
Definition / general
  • Recently described aggressive variant of penile carcinoma
  • Middle aged men
  • Foreskin inner mucosa
  • Most likely of sweat gland origin
  • HPV 16 DNA found in all reported cases
Clinical features
  • All reported patients presented with inguinal nodal metastases with clear cells and sclerotic basement membrane material
Case reports
  • Excision with wide surgical margin
Gross description
  • Large, exophytic and partially ulcerated
  • Size 2.5 - 5.5 cm
Microscopic (histologic) description
  • Solid proliferation of large neoplastic clear cells
  • Marked nuclear atypia
  • Extensive geographical necrosis
  • Angiolymphatic invasion is common
  • Warty PeIN may be found at surface
Positive stains
Differential diagnosis
Back to top
Image 01 Image 02