Penis & scrotum


Giant condyloma acuminatum

Last author update: 1 February 2010
Last staff update: 30 August 2022

Copyright: 2002-2023,, Inc.

PubMed Search: Giant condyloma acuminatum penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
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Cite this page: Chaux A, Cubilla AL. Giant condyloma acuminatum. website. Accessed September 28th, 2023.
Definition / general
  • Also called Buschke-Löwenstein tumor
  • Also called verrucous carcinoma by some authors but most authors consider them to be separate entities
  • Patients tend to be older than those with condyloma acuminatum
  • Usually involves foreskin and coronal sulcus; also glans, perianal region
  • Low risk genotypes (HPV 6 and 11) predominate
Clinical features
  • Associated with poor hygiene in uncircumcised men
  • Intermediate properties between condyloma and warty carcinoma - tends to recur locally and destroy surrounding tissue
  • Malignant transformation may occur after many years
  • Radical surgical excision allows a complete histological examination and assessment of tumor free resection margins (Dermatology 2009;218:56)
  • Also chemoradiation, intralesional interferon treatment for condyloma
Clinical images

Images hosted on other servers:

Perianal tumor - cauliflower-like mass

Pre and post intralesional interferon

Gross description
  • 5 - 10 cm cauliflower-like verruciform tumor with cobblestone surface
  • Cut surface shows papillomatous growth with sharp demarcation from underlying stroma
  • Cutaneous fistulae sometimes observed
Gross images

AFIP images
Massive multinodular exophytic mass

Massive multinodular exophytic mass

Microscopic (histologic) description
  • Resembles condyloma (papillae with prominent fibrovascular cores, koilocytosis, broad pushing base) but with more prominent bulbous expansion into underlying tissue
  • Characteristically exhibits an endophytic pattern of growth and can invade deep anatomical tissues
  • Atypia or malignant change (in situ or invasive squamous cell carcinoma) may also be present
Microscopic (histologic) images

AFIP images

Features of condyloma

Images hosted on other servers:

Papillomatous tumor with few koilocytes

Band-like mononuclear infiltrate

Differential diagnosis
  • Carcinoma cuniculatum: no koilocytosis, verrucous features and endophytic burrowing pattern of growth
  • Papillary carcinoma: no koilocytosis, complex papillae with irregular fibrovascular cores and definite invasion
  • Verrucous carcinoma: no koilocytosis, no prominent papillae with fibrovascular cores; pushing tumor base
  • Warty carcinoma: probably related, has clearly malignant histology and jagged borders with stroma
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