Penis & scrotum
Other malignancies

Topic Completed: 1 April 2010

Minor changes: 28 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Primary lymphoma penis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2020: 97
Page views in 2021 to date: 9
Cite this page: Chaux A, Cubilla AL. Lymphoma. website. Accessed January 24th, 2021.
Definition / general
  • Primary penile lymphomas are exceedingly rare
  • Secondary involvement is somewhat common in disseminated disease
  • All penile compartments may be affected
Clinical features
  • Non-Hodgkin B or T cell lymphoma is more common than Hodgkin lymphoma
  • Confirmation and phenotyping is done by immunohistochemistry
Case reports
Clinical images

AFIP images

5 cm ulcer of dorsum of penis


Gross description
  • Fleshy white neoplasm, nonspecific ulceration
Gross images

AFIP images

Irregular, shaggy, white-gray mass

Microscopic (histologic) description
  • Dense infiltrate of atypical lymphocytes
Microscopic (histologic) images

AFIP images

Large cell lymphoma

Differential diagnosis
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