Penis & scrotum
Other malignancies
Primary lymphoma
Authors: Alcides Chaux, M.D., Antonio L. Cubilla, M.D.
Topic Completed: 1 April 2010
Minor changes: 14 February 2019
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Primary lymphoma penis
Table of Contents
Definition / general | Sites | Clinical features | Case reports | Treatment | Clinical images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Chaux A, Cubilla AL. Primary lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/penscrotumlymphoma.html. Accessed August 7th, 2020.
Definition / general
- Primary penile lymphomas are exceedingly rare
- Secondary involvement is somewhat common in disseminated disease
Sites
- All penile compartments may be affected
Clinical features
- Non-Hodgkin B or T cell lymphoma is more common than Hodgkin lymphoma
- Confirmation and phenotyping is done by immunohistochemistry
Case reports
- 65 year old man with primary peripheral T cell lymphoma (Zhonghua Nan Ke Xue 2008;14:1003)
- MALT lymphoma involving foreskin (Leuk Lymphoma 2004;45:1699)
Treatment
- Recommended to avoid radiation therapy, which has severe side effects (Acta Haematol 2008;120:150)
Clinical images
AFIP images
5 cm ulcer of dorsum of penis
Postchemotherapy
Gross description
- Fleshy white neoplasm, nonspecific ulceration
Gross images
AFIP images
Irregular, shaggy, white-gray mass
Microscopic (histologic) description
- Dense infiltrate of atypical lymphocytes
Microscopic (histologic) images
AFIP images
Large cell lymphoma
