Penis & scrotum
Mondor phlebitis

Topic Completed: 1 February 2010

Minor changes: 28 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Mondor phlebitis

Alcides Chaux, M.D.
Antonio L. Cubilla, M.D.
Page views in 2020: 986
Page views in 2021 to date: 323
Cite this page: Chaux A, Cubilla AL. Mondor phlebitis. website. Accessed April 15th, 2021.
Definition / general
  • Also called superficial thrombophlebitis, Mondor disease or (incorrectly) nonvenereal sclerosing lymphangitis
  • Preferentially affects the superficial dorsal penile vein
  • Firm, subcutaneous cord-like structure(s) along dorsal shaft of penis or around coronal sulcus, due to massive thrombosis of superficial venous plexus of penis
  • Causes: neoplasm, mechanical trauma during vigorous intercourse following sexual abstinence, sickle cell disease (J Am Osteopath Assoc 2003;103:102), long airline flight (Int J STD AIDS 2005;16:510), varicose vein surgery (J R Soc Med 2001;94:292) or herpes simplex infection
Clinical features
  • Firm, subcutaneous cord-like structures, mostly parallel to coronal sulcus
  • Foreskin and dorsal midline of penile shaft can also be affected
  • Pain and tenderness in a minority of cases, especially during erection
  • Almost always self limited (spontaneous regression in 4 - 8 weeks) but associated with considerable psychological stress
  • Temporary sexual abstinence
Clinical images

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Deep venous thrombosis

Firm, cord-like lesion

Gross description
  • Firm, subcutaneous cord-like structures along dorsal shaft of penis or around coronal sulcus
Microscopic (histologic) description
  • Prominent vessels with plump endothelial cells and thickened (sclerotic) blood vessel walls (mainly veins), with occasional vessel showing complete occlusion of lumen
  • Perivascular inflammatory infiltrate composed of lymphocytes, histiocytes and plasma cells
  • No evidence of lymphatic involvement
Microscopic (histologic) images

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Arteriole and venule with plump endothelial cells

Differential diagnosis
  • Cutaneous polyarteritis nodosa: vasculitis involving small and medium sized arteries of the dermis and subcutaneous tissue
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