Nonneoplastic placental conditions and abnormalities


Hemorrhagic endovasculitis / vasculopathy

Last author update: 1 October 2011
Last staff update: 31 August 2020

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PubMed Search: Hemorrhagic endovasculitis vasculopathy

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Hemorrhagic endovasculitis / vasculopathy. website. Accessed June 1st, 2023.
Definition / general
  • Endothelial injury with vascular necrosis
  • Existence as a separate lesion from fetal thrombotic vasculopathy (FTV) is debated by some
  • Associated with maternal hypertension, fetal neurologic injury, growth restriction, tissue hypoxia and increased perinatal morbidity / mortality
  • Etiology is unknown
Microscopic (histologic) description
  • Vascular wall injury with extravasated red cells, endothelial / medial hyperplasia, red cell fragmentation and hemosiderin deposition
  • Changes similar to intrauterine fetal demise but are focal rather than diffuse
  • May be accompanied by chronic villitis, chorionic vascular thrombosis, erythroblastosis, villous fibrosis, infarction and evidence of meconium exposure
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